Michael S. VanNieuwenhze

Educational Highlights

• 1984 - B.A. Kalamazoo College
• 1988 - M.A. Yale University
• 1992 - Ph.D. Indiana University
• 1992-1994 - NIH Postdoctoral Fellow, The Scripps Research Institute

Work History

• 1994-2000 - Senior Organic Chemist, Eli Lilly and Company
• 2001-2002 - Research Scientist, Eli Lilly and Company
• 2002-Present - Appointed to UCSD Chemistry faculty

Publications

• The Total Synthesis of Lipid I. VanNieuwenhze, M. S.; Mauldin, S. C.; Zia-Ebrahimi, M.; Aikins, J. A.; Blaszczak, L. C. J. Am Chem. Soc. (2001), 123(29), 6983-6988. [link]

• Synthesis of the C(3)-C(15) segment of rutamycin B via a C(8)-C(9) fragment assembly aldol reaction: metal dependence of the aldehyde and enolate diastereofacial selectivities. Gustin, Darin J.; VanNieuwenhze, Michael S.; Roush, William R. Tet. Lett. (1995), 36(20), 3447-3450. [link]

• Diastereoselective aldol reactions of chiral aldehydes and chiral methyl ketones: dependence of stereoselectivity on the metal enolate, the aldehyde 2,3-stereochemistry, and the aldehyde b-alkoxy protecting group. Gustin, D.J.; VanNieuwenhze, M. S.; Roush, W. R. Tet. Lett. (1995), 36(20), 3443-3446. [link]

• The asymmetric dihydroxylation cis-allylic and homoallylic alcohols. VanNieuwenhze, M. S.; Sharpless, K. B. Tet. Lett. (1994), 35(6), 843-846. [link]

• [(Z)-g-[(Diisopropylidene-a-D-mannopyranosyl)oxy]allyl]tributylstannane: A New Chiral Reagent for the Asymmetric a-Hydroxyallylation of Aldehydes. Roush, W. R.; VanNieuwenhze, M. S. J. Am Chem. Soc., 1994, 116(19), 8536-8543. [link]

• Catalytic Asymmetric Dihydroxylation. Kolb, H. C.; VanNieuwenhze, M. S.; Sharpless, K. B. Chem. Reviews, 1994, 94(8), 2483-2547. [link]

• Kinetic resolution of racemic olefins via asymmetric dihydroxylation. VanNieuwenhze, M. S.; Sharpless, K. B. J. Am Chem. Soc., 1993, 115(17), 7864-7865. [link]

• A stereochemically general synthesis of 2-deoxyhexoses via the asymmetric allylboration of 2,3-epoxy aldehydes. Roush, W. R.; Straub, J. A.; VanNieuwenhze, M. S. J. Org. Chem., 1991, 56(4), 1636-1648. [link]

• An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones. Roush, W. R; Bannister, T. D; Wendt, M. D; VanNieuwenhze, M. S; Gustin, D. J; Dilley, G. J; Lane, G. C; Scheidt, K. A; Smith, W. J 3rd. J. Org. Chem., 2002, 67(12), 4284-4289. [link]

• The first total synthesis of lipid II: the final monomeric intermediate in bacterial cell wall biosynthesis.VanNieuwenhze Michael S; Mauldin Scott C; Zia-Ebrahimi Mohammad; Winger Brian E; Hornback William J; Saha Shankar L; Aikins James A; Blaszczak Larry C J. Am Chem. Soc., 2002, 124(14), 3656-60. [link]