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L. Garcia-Ortega, J. Stephen and S. Joseph. 2008. Precise alignment of peptidyl tRNA by the decoding center is essential for EF-G-dependent translocation. Molecular Cell 32: 292-299. Full Text

S. M. Studer and S. Joseph. 2007. Binding of mRNA to the bacterial translation initiation complex. Methods in Enzymology 430: 31-44. Full Text

C. M. Dunham, M. Selmer, S. S. Phelps, A. C. Kelly, T. Suzuki, S. Joseph and V. Ramakrishnan. 2007. Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit. RNA 13: 817-823. Full Text

J. S. Feinberg and S. Joseph. 2006. A conserved base pair between tRNA and 23S rRNA in the peptidyl transferase center is important for peptide release. J. Mol. Biol. 364: 1010-1020. Full Text

I. K. Ali, L. Lancaster, J. S. Feinberg, S. Joseph and H. F. Noller. 2006. Deletion of a conserved, central ribosomal intersubunit RNA bridge. Molecular Cell 23: 865-874. Full Text

T. Komoda, N. S. Sato, S. S. Phelps, N. Namba, S. Joseph and T. Suzuki. 2006. The A-site finger in 23S rRNA acts as a functional attenuator for translocation. J. Biol. Chem. 281: 32303-32309. Full Text

S. S. Phelps, C. Gaudin, S. Yoshizawa, C. Benitez, D. Fourmy and S. Joseph. 2006. Translocation of a tRNA with an extended anticodon through the ribosome. J. Mol. Biol. 360: 610-622. Full Text

S. M. Studer and S. Joseph. 2006. Unfolding of mRNA secondary structure by the bacterial translation initiation complex. Molecular Cell 22: 105-115. Full Text PREVIEW NEWS

J. S. Feinberg and S. Joseph. 2006. Ribose 2'-hydroxyl groups in the 5' strand of the acceptor arm of P-site tRNA are not essential for EF-G catalyzed translocation. RNA 12: 580-588. Full Text

K. Y. Sanbonmatsu, S. Joseph and C. S. Tung. 2005. Simulating movement of tRNA into the ribosome during decoding. Proc. Natl. Acad. Sci. USA. 102: 15854-15859. Full Text

S. S. Phelps and S. Joseph. 2005. Non-bridging phosphate oxygen atoms within the tRNA anticodon stem-loop are essential for ribosomal A site binding and translocation. J. Mol. Biol. 349: 288-301. Full Text

S. Ghosh and S. Joseph. 2005. Nonbridging phosphate oxygens in 16S rRNA important for 30S subunit assembly and association with the 50S ribosomal subunit. RNA 11: 657-667. Full Text

S. S. Phelps, A. Malkiewicz, P. F. Agris and S. Joseph. 2004. Modified nucleotides in tRNA-Lys and tRNA-Val are important for translocation. J. Mol. Biol. 338: 439-444. Full Text

K. Y. Sanbonmatsu and S. Joseph. 2003. Understanding discrimination by the ribosome: Stability testing and groove measurement of codon-anticodon pairs. J. Mol. Biol. 328: 33-47. Full Text

S. M. Studer, J. S. Feinberg and S. Joseph. 2003. Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome. J. Mol. Biol. 327: 369-381. Full Text

S. Joseph. 2003. After the ribosome structure: How does translocation work? RNA 9: 160-164. Full Text

S. S. Phelps, O. Jerinic and S. Joseph. 2002. Universally conserved interactions between the ribosome and the anticodon stem-loop of A site tRNA important for translocation. Molecular Cell 10: 799-807. Full Text

C. Tung, S. Joseph and K. Y. Sanbonmatsu. 2002. All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nature Structural Biology 9: 750-755. Full Text

C. Ma, N. A. Baker, S. Joseph and J. A. McCammon. 2002. Binding of aminoglycoside antibiotics to the small ribosomal subunit: a continuum electrostatics investigation. J. Am. Chem. Soc. 124: 1438-1442. Full Text

J. S. Feinberg and S. Joseph. 2001. Identification of molecular interactions between P-site tRNA and the ribosome essential for translocation. Proc. Natl. Acad. Sci. USA. 98: 11120-11125. Full Text

N. A. Baker, D. Sept, S. Joseph, M. J. Holst, J. A. McCammon. 2001. Electrostatics of cellular components: Application to microtubules and the ribosome. Proc. Natl. Acad. Sci. USA. 98: 10037-10041. Full Text

O. Jerinic and S. Joseph. 2000. Conformational changes in the ribosome induced by translational miscoding agents. J. Mol. Biol. 304: 707-713. Full Text

S. Joseph, M. L. Whirl, D. Kondo, H. F. Noller and R. B. Altman. 2000. Calculation of the relative geometry of tRNAs in the ribosome from directed hydroxyl radical probing data. RNA 6: 220-232. Full Text

S. Joseph and H. F. Noller. 2000. Directed hydroxyl radical probing using Fe(II) tethered to RNA. Methods Enzymol. Vol 318: 175-190.

R. R. Samaha, S. Joseph, B. O'Brien, T. W. O'Brien and H. F. Noller. 1999. Site-directed hydroxyl radical probing of 30S ribosomal subunits by using Fe(II) tethered.to an interruption in the 16S rRNA chain. Proc. Natl. Acad. Sci. USA. 96: 366-370. Full Text

S. Joseph and H. F. Noller. 1998. EF-G-catalyzed translocation of anticodon stem-loop analogs of transfer RNA in the ribosome. EMBO J. 17: 3478-3483. Full Text

S. Joseph, B. Weiser and H. F. Noller. 1997. Mapping the inside of the ribosome with an RNA helical ruler. Science 278: 1093-1098. Full Text

S. Joseph and H. F. Noller. 1996. Mapping the rRNA neighborhood of the acceptor end of tRNA in the ribosome. EMBO J. 15: 910-916. Abstract

H. F. Noller, R. Green, G. Heilek, V. Hoffarth, A. Huttenhofer, S. Joseph, I. Lee, K. Lieberman, A. Mankin, C. Merryman, T. Powers, E. V. Puglisi, R. R. Samaha, and B. Weiser. 1995. "Structure and function of ribosomal RNA" in A. Matheson, J. Davies, P. Dennis and W. Hill (editors). Proceedings of frontiers in translation, an international ribosome conference, Victoria, B.C., Biochem. Cell Biol. 73: 997-1009.

S. Joseph and J. M. Burke. 1993. Optimization of an anti-HIV hairpin ribozyme by in vitro selection. J. Biol. Chem. 268: 24515-24518.

A. Berzal-Herranz, S. Joseph, B. M. Chowrira, S. E. Butcher and J. M. Burke. 1993. Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme. EMBO J. 12: 2567-2574.

S. Joseph, A. Berzal-Herranz, B. M. Chowrira, S. E. Butcher and J. M. Burke. 1993. Substrate selection rules for the hairpin ribozyme determined by in vitro selection, mutation, and analysis of mismatched substrates. Genes & Dev. 7: 130-138.

A. Berzal-Herranz, S. Joseph and J. M. Burke. 1992. In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions. Genes & Dev. 6: 129-134.