Esquenazi, E., Coates, C., Simmons, L., Gonzalez, D., Gerwick, W.H., Dorrestein, P.C. Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Molecular BioSystems. Accepted.

Simmons, T. L., Coates R.C., Clark B. R., Engene N., Gonzalez D., Esquenazi, E., Dorrestein P. C., Gerwick W. H. Biosynthetic Origin of Natural Products Isolated from Marine Microorganism-Invertebrate Assemblages. Proc. Natl. Acad. Sci. USA. Accepted.

Zhang, J., Van Lanen, S. G., Ju, J., Liu, W. Dorrestein, P.C., Li, W., Kelleher, N. L., Shen, B. A. Phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc. Natl. Acad. Sci. USA. Accepted.

Meluzzi, D., Zheng, W.H., Hensler, M., Nizet, V., Dorrestein, P. C. Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorganic & Medicinal Chemistry Letters. Accepted. doi:10.1016/j.bmcl.2007.10.104

2007

Calderone CT, Iwig DF, Dorrestein PC, Kelleher NL, Walsh CT. Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol. (2007) Jul;14(7):835-46.

Winter JM, Moffitt MC, Zazopoulos E, McAlpine JB, Dorrestein PC, Moore BS. Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem. (2007) Jun 1;282(22):16362-8.

Yin, J., Straight, P.D., Hrvatin, S., Dorrestein, P. C., Bumpus, S., Jao, C., Kelleher, N. L., Kolter, R., Walsh, C.T., Genome-wide high throughput mining of natural product biosynthetic gene clusters by phage display. Chemistry and Biology,(2007) Mar;14(3):303-12.

2006

Garneau-Tsodikova, S., Dorrestein, P.C., Kelleher, N.L., Walsh, C. T. Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society (2006) 128(39); 12600-12601.

Dorrestein, P.C., Kelleher, N.L., Dissecting Non-ribosomal and Polyketide Biosynthetic Machineries Using Electrospray Ionization Fourier-Transform MassSpectrometry. Nat Prod Rep. (2006) Dec;23(6):893-918.

Dorrestein P.C., Bumpus S. B., Calderone C. T., Garneau-Tsodikova S., Aron Z. D., Straight P.D., Kolter R., Walsh C. T. and Kelleher N. L. Facile Detection of Acyl- and Peptidyl- intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions During Tandem Mass Spectrometry. Biochemistry (2006) 45 (6), 1537 -1546.

Dorrestein, P.C., Van Lanen, S. G., Li, W. Zhao, C., Deng, Z., Shen, B., Kelleher, N.L., The Bifunctional Glyceryl Transferase/Phosphatase OzmB Belonging to the HAD Superfamily That Diverts 1,3-Bisphosphoglycerate into Polyketide Biosynthesis. Journal of the American Chemical Society (2006) 128 (32), 10386 –10387.

Calderone, C.T., Kowtoniuk, W.E., Kelleher, N.L., Walsh, C.T., Dorrestein, P.C. Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of B. subtilis. Proc. Natl. Acad. Sci. USA. (2006) 103, 8977-8982.

Dorrestein, P.C., Blackhall, J., Straight, P.D., Fischbach, M.A., Garneau-Tsodikova, S., Edwards, D.J., McLaughlin, S., Lin, M., Gerwick, W.H., Kolter, R., Walsh, C.T., Kelleher, N.L. Activity Screening of Carrier Domains within Nonribosomal Peptide Synthetases Using Complex Substrate Mixtures and Large Molecule Mass Spectrometry. Biochemistry (2006) 45(6), 1537-1546.

Howarth, M., Chinnapen, D.J.F., Gerrow, K., Dorrestein, P.C., Grandy, M.R., Kelleher, N.L., El-Husseini, A., Ting, A.Y. A Monovalent Streptavidin with a Single Femtomolar Biotin Binding Site. Nature Methods (2006) 3(4), 267-273.

Hicks, L.M., Mazur, M.T., Miller, L.M., Dorrestein, P.C., Schnarr, N.A., Khosla, C., Kelleher, N.L. Investigating Nonribosomal Peptide and Polyketide Biosynthesis by Direct Detection of Intermediates on >70 kDa Polypeptides using Fourier-Transform Mass Spectrometry ChemBiochem (2006) 7, 904-907.

Van Lanen S.G., Lin S., Dorrestein P.C., Kelleher N.L., Shen B., Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. J. Biol. Chem. (2006) 281, 29633-40.

2005

Dorrestein, P.C., Yeh, E., Garneau-Tsodikova, S., Kelleher, N.L., Walsh, C.T., Dichlorination of a Pyrrolyl-S-Carrier protein by FADH2-Dependent Halogenase PltA During Pyoluteorin Biosynthesis. Proceedings of the National Academy of Sciences of the United States of America (2005) 102(39), 13843-13848.

Aron, Z.D., Dorrestein, P.C., Blackhall, J.R., Kelleher, N.L., Walsh, C.T. Characterization fo the New Tailoring Domain in Polyketide Biogenesis: The Amine Transferase Domain of MycA in the Mycosubtilin Gene Cluster. Journal of the American Chemical Society (2005) 127(43), 14986-14987.

Van Lanen, S.G., Dorrestein, P.C., Christenson, S.D., Liu, W., Ju, J., Kelleher, N.L., and Shen, B. Biosynthesis of the b -Amino Acid Moiety of the Enediyne Antitumor Antibiotic C-1027 Featuring b-Amino Acyl-S-carrier Protein Intermediates. Journal of the American Chemical Society. (2005) 127(33), 11594-5.

Garneau, S., Dorrestein, P.C., Kelleher, N.L., and Walsh, C.T. Characterization of the Formation of the Pyrrole Moiety during Clorobiocin and Coumermycin A1 Biosynthesis. Biochemistry. (2005) 44, 2770-2780.

Zhai, H., Dorrestein, P.C., Chatterjee, A., Begley, T.P., McLafferty, F.W. Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry. Journal of American Society of Mass. Spectrometry. (2005) 16(7), 1052-9.

Burns, K.C., Baumgart, S., Dorrestein, P.C., Zhai, H., McLafferty, F.W., and Begley, T.P. Reconstitution of a New Cysteine Biosynthetic Pathway in Mycobacterium tuberculosis. Journal of the American Chemical Society. (2005) 127(33), 11602-3.

Dorrestein P.C., and Begley, T.P. Oxidative cascades: a facile biosynthetic stategy for the assembly of complex molecules. Bioorganic chemistry. (2005) 33(3), 136-148. (review).

2004

Settembre E.C., Dorrestein, P.C., Zhai,H., Chatterjee, A., McLafferty, F.W., Begley, T.P., and Ealick S.E. Structure of the ThiS/ThiG complex Essential for Thiamin Biosynthesis in Bacillus subtilis. Biochemistry. (2004) 43(37), 11647-57.

Dorrestein, P.C., Zhai, H., McLafferty F.W., and Begley, T.P. The Biosynthesis of the Thiazole Phosphate Moiety of Thiamin (Vitamin B1): The Sulfur Transfer Mediated by the Sulfur Carrier Protein ThiS. Chemistry and Biology. (2004) 11(10), 1373-81.

Dorrestein, P.C., Zhai, H., Taylor, S., McLafferty, F., and Begley, T.P. The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase. Journal of the American Chemical Society. (2004)126(10), 3091-6.

2003

Kurnasov, O., Jablonski, L., Polanuyer, B., Dorrestein, P.C., Begley, and T.P., Ostermann, A. Aerobic tryptophan degradation pathway in bacteria: novel kynurenine formamidase. FEMS microbiology letters. (2003) 227(2), 219-227.

Park, J., Dorrestein, P.C., Zhai, H., Kinsland, C., McLafferty, F.W., and Begley, T.P., Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. (2003) 42, 12430-12438.

Dorrestein, P.C., Poole, K., and Begley, T.P., The formation of the pyoverdine chromophore by an oxidative cascade. Organic Letters. (2003) 5(13), 2215-2217.

Maggio-Hall, L., Dorrestein, P.C., Begley T.P., and Escalante-Semerena J. C. Formation of the Dimethylbenzimidazole Ligand of Coenzyme B12 under physiological conditions by a facile oxidative cascade. Organic letters. (2003) 5(13), 2211-2213.

Settembre, E.C., Dorrestein, P.C., Park, J., Augustine, A., Begley, T.P., and Ealick, S.E. Structural and Mechanistic studies of ThiO, a Glycine Oxidase Essential for Thiamin Biosynthesis in Bacillus subtilis. Biochemistry. (2003) 42(10), 2971-2981.

1999-2002

Anand, R., Dorrestein, P.C., Kinsland, C., Begley, T.P., and Ealick, S.E. Structure of Oxalate Decarboxylase From Bacillus subtilis at 1.75 Å Resolution. Biochemistry. (2002) 41(24), 7659-7669.

Begley, T.P., Kinsland, C., Mehl, R.A., Ostermann, A., and Dorrestein, P.C. The Biosynthesis of Nicotinamide Adenine Dinucleotides in Bacteria. Vitamins and Hormones (San Diego, CA, United States). (2001) 61,103-119 (review).

Mansour, G., Creedon, W., Dorrestein, P.C., Maxka, J., MacDonald, J.C., and Helburn, R. Synthesis and Physical Characterization of Some New Hydrophobic Forms of the Solvatochromic N,N-dialkyl-p-nitroanilines. Journal of Organic Chemistry. (2001) 66(11), 4050-4054.

MacDonald, J.C., Dorrestein, P.C., and Pilley, M.M. Design of Supramolecular Layers via Self-Assembly of Imidazole and Carboxylic acids. Crystal Growth & Design. (2001) 1(1), 18-29.

MacDonald, J.C., Dorrestein, P.C., Pilley, M.M., Foote, M.M., Lundburg, J.L., Henning, R.W., Schultz, A.J., and Manson, J.L. Design of Layered Crystalline Materials Using Coordination Chemistry and Hydrogen Bonds. Journal of the American Chemical Society. (2000) 122(47), 11692-11702.

MacDonald, J.C., and Dorrestein, P.C., Design of robust molecular layers using ionic hydrogen bonds and metal-ligand interactions. Transactions of the American crystallographic association. (1999) Volume date 1998, 33, 117-127.